GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | trans | rs1056667 | 1 | rs9467778 | chr6:26534743 | ZNF322B | chr9:99957633-99961910:- | 0.46 | 8.02 | 1.27E-14 | Educational attainment |
| BLCA | trans | rs1056667 | 1 | rs9467779 | chr6:26536687 | ZNF322B | chr9:99957633-99961910:- | -0.46 | -8.07 | 9.0E-15 | Educational attainment |
| BLCA | trans | rs1056667 | 1 | rs9467782 | chr6:26542773 | ZNF322B | chr9:99957633-99961910:- | 0.46 | 8.01 | 1.43E-14 | Educational attainment |
| BLCA | trans | rs1056667 | 1 | rs9467783 | chr6:26542894 | ZNF322B | chr9:99957633-99961910:- | 0.46 | 8.02 | 1.27E-14 | Educational attainment |
| BLCA | trans | rs1056667 | 1 | rs9467787 | chr6:26556769 | ZNF322B | chr9:99957633-99961910:- | 0.47 | 8.29 | 1.88E-15 | Educational attainment |
| BLCA | trans | rs1056667 | 1 | rs9467791 | chr6:26562486 | ZNF322B | chr9:99957633-99961910:- | -0.49 | -8.48 | 5.06E-16 | Educational attainment |
| BLCA | trans | rs1056667 | 1 | rs9467796 | chr6:26568411 | ZNF322B | chr9:99957633-99961910:- | 0.46 | 8.07 | 9.07E-15 | Educational attainment |
| BLCA | trans | rs1056667 | 1 | rs9467797 | chr6:26568473 | ZNF322B | chr9:99957633-99961910:- | 0.46 | 8.07 | 9.07E-15 | Educational attainment |
| BLCA | trans | rs1056667 | 1 | rs9986382 | chr6:26550619 | ZNF322B | chr9:99957633-99961910:- | 0.47 | 8.27 | 2.21E-15 | Educational attainment |
| BRCA | cis | rs1000083 | 1 | rs1000083 | chr5:96533469 | ERAP2 | chr5:96211644-96255398:+ | -0.28 | -4.05 | 5.6E-5 | Cisplatin-induced ototoxicity |
| BRCA | cis | rs7714584 | 1 | rs1000113 | chr5:150240076 | LOC134466 | chr5:150310000-150326146:- | 0.33 | 7.52 | 1.15E-13 | Crohn's disease |
| BRCA | cis | rs1109501 | 1 | rs10003641 | chr4:71340427 | AMTN | chr4:71384298-71398459:+ | 0.26 | 7.54 | 1.01E-13 | Alcoholism (heaviness of drinking) |
| BRCA | cis | rs7659604 | 1 | rs10005932 | chr4:122664782 | EXOSC9 | chr4:122722472-122738175:+ | 0.13 | 4.27 | 2.1E-5 | Type 2 diabetes |
| BRCA | cis | rs6831256 | 1 | rs10007119 | chr4:3473066 | LRPAP1 | chr4:3514290-3534224:- | 0.11 | 3.85 | 0.000127 | Triglycerides;Cholesterol, total;LDL cholesterol |
| BRCA | cis | rs4691139 | 1 | rs10007789 | chr4:165890377 | TRIM61 | chr4:165875600-165898818:- | 0.25 | 7.81 | 1.35E-14 | Ovarian cancer in BRCA1 mutation carriers |